Coarsening of the facial features

Maroteaux-Lamy syndrome , also called Mucopolysaccharidosis Vi , uncommon hereditary metabolic disease characterized by dwarfism , hearing loss , and progressive skeletal deformity. Onset of the disease is usually in early childhood, with some coarsening of facial features evident by the first birthday. Eye changes, consisting of corneal opacification and hypertelorism, or unusual widening of the space between the eyes, and enlargement of the liver and spleen are also features of the disease. Intelligence is normal, but the lifespan is greatly shortened; affected persons seldom survive beyond age
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Coarse facial features

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Orphanet: Hurler syndrome MPS1H

Absence of fine and sharp appearance of brows, nose, lips, mouth, and chin, usually because of rounded and heavy features or thickened skin with or without thickening of subcutaneous and bony tissues. Term Hierarchy. Phenotypic abnormality Abnormality of head or neck Abnormality of the head Abnormality of the face Abnormal facial shape Coarse facial features Pugilistic facies. Conditions with this feature. Most individuals have skeletal anomalies e. Peak incidence is at age one to two years. Beckwith-Wiedemann syndrome BWS is a growth disorder variably characterized by neonatal hypoglycemia, macrosomia, macroglossia, hemihyperplasia, omphalocele, embryonal tumors e.
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Maroteaux-Lamy syndrome

However, like any other anti-epileptic drug AED , unpleasant side-effects are not rare. The aim of this study is the evaluation of dermatological troubles related to chronic PHT usage in female patients. Method: Between , new patients underwent investigation for epilepsy at the Multidisciplinary Clinic for Epilepsy in our State. In this sample were AED users at the time of the first assessment.
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